When you participate in this research study, it will help healthcare providers to understand more about children with MIS-C. Please consider taking part in this important research.
The COVID MUSIC Study will help to contribute to a better understanding of the best way to treat children with MIS-C.
Questions? Contact us.
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Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare but serious complication of COVID-19 involving inflammation of organs, including the heart, lungs, kidneys, brain, skin and eyes. Because MIS-C is a new condition related to COVID-19, we are still learning about its causes, effects, and long-term impact. “Long-Term Outcomes after the Multisystem Inflammatory Syndrome In Children”, the COVID MUSIC Study, is an important research study funded by NIH and the National Heart, Lung, and Blood Institute. About 600 young people with MIS-C will be enrolled at leading children’s medical centers in the U.S. and Canada. This research study will help us learn more about Multisystem Inflammatory Syndrome in Children and its effects on the long-term health of children who have had MIS-C.
This study is about a COVID-19 condition called Multisystem Inflammatory Syndrome in Children (MIS-C).
We do not know the long-term effects of MIS-C on the heart or other body systems. This study will help us learn more.
We are enrolling about 600 young people with MIS-C from leading children’s medical centers in the U.S. and Canada.
The study lasts up to 5 years, during which participants may have up to 7 visits. We will try to schedule these visits at the same time as routine care clinic visits. These will usually occur about 2 weeks, 6 weeks, and 6 months after hospital discharge. If a participant has low function/squeeze of the heart, coronary artery enlargement, or heart rhythm problems, doctors may want to see them in clinic more often as part of routine care.
Medical Chart Review: We will review medical charts to obtain information during the hospital course and outpatient follow-up clinic visits related to MIS-C. We will also obtain information and reports from the heart imaging tests that are performed as part of medical care.
Yearly Contact: We will look at participants’ medical charts and contact them to conduct a brief annual medical history form at 1 year and then once a year until 5 years after diagnosis of MIS-C. We will ask about any operations, tests, or times in the hospital, as well as about how they are doing. We will also ask about medications or new health problems. We may contact participants by phone, text, email, or we may schedule a telehealth, or virtual, visit. Each yearly visit will take about 20 minutes.
Genetic Testing of Participant and Biological Parents (Optional): We are trying to understand how differences in DNA (genetic make-up) may make young people susceptible to developing MIS-C. When studying genetic variation, it is also helpful to have samples from the biological parents of the person with the disease to compare the genetic data. These blood or saliva samples from participants and their parents are optional and can be collected at any time during the study.